Development and characterisation of biodegradable chitosan-herbal composite films for wound dressing applications

Abstract

This study aims to develop a novel herbal curative film for wound dressing by holding a combination of herbs
(Eugenia jambolana, Aerva lanata), and chitosan, acting as a drug-releasing agent on the wound surface. The films are formed using a simple film-casting technique with citric acid as the solvent and glycerol as a plasticiser. Surface morphology is carried out using scanning electron microscopy, and the chemical composition is confirmed through Energy Dispersive X-ray Analysis (EDAX). The physical properties of the film are assessed using standard methods. Bioevaluation characteristics like antimicrobial efficacy are measured in terms of zone of inhibition against Bacillus subtilis and Pseudomonas aeruginosa. Additionally, microbial penetration, drug release activity, cytotoxicity, and contact dermatitis are analysed as per standard protocols. The results demonstrate that the developed films exhibit promising performance and potential in biodegradable wound dressing applications with desirable wound healing properties.