Synthesis of fluorinated ferrocene derivatives for their thermal behavior and their In Silico studies in designing of Potential Breast Cancer Inhibitors

Abstract

The docking studies of the different fluorinated ferrocene derivatives were carried out against estrogen receptor enzymes. The docking results are very much comparable with standard drug tamoxifen. The designed fluorinated ferrocene derivatives show similarity in binding as tamoxifen exhibits estrogen receptor enzymes in silico.

Docking studies reveal that designed fluorinated ferrocene derivatives have potential against breast cancer in silico. The ADME properties of some of the designed compounds were indicative for the drug likeness of compounds.

All the designed fluorinated derivatives were synthesized and have been evaluated for their thermal behavior.